Incidence and predictors of QT interval prolongation in the intensive care units of a tertiary pulmonary center
By Zeinab Hosseinpoor, Behrooz Farzanegan, Seyyed Reza Seyyedi, Mehdi Rajabi, Habib Emami, Shadi Baniasadi
European Respiratory Journal 2018 52: PA1978; DOI: 10.1183/13993003.congress-2018.PA1978
Introduction: Critically ill patients are more prone to prolongation of QT interval (QT) because of the severity of illness and medication complexity.
Aims: We aimed to determine the rate and risk factors of corrected QT interval (QTc) prolongation in the intensive care unit (ICU) patients.
Methods: A prospective observational study was conducted for six months. The patients above 18 years old admitted to the ICUs (medical, surgical, emergency) of a pulmonary referral center included in the study. All patients were evaluated with a 12-lead electrocardiogram (ECG) on day 1, 3 and 5 of admission. Baseline demographics, past medical history, current medical diagnosis, concomitant medications, laboratory data, heart rate, and QTc were collected for each patient. QTc >460 ms in male and >470 ms in female or increase >60ms above baseline was defined as prolonged QTc. The relationship between QTc prolongation and its predictors was examined using logistic regression models.
Results: One hundred three consecutive patients (61.1±17.8 years; 60.2% male; baseline QTc 408.5±32.1 ms) were evaluated. Diseases of the respiratory system (39.8%) and neoplasms (16.5%) were the most common primary diagnosis. The rate of QTc prolongation was 23% within 5 days of ICU admission. Male sex (OR 6.6, CI 1.2-35.7), administration of azithromycin (OR 13.2, CI 1.2-142.0) and amiodarone (OR 5.5, CI 1.0-29.9) were associated with an increased risk of QTc prolongation (p<0.05).
Conclusions: Prolongation of QTc are common among ICU admitted patients. Increased vigilance in male patients and patients receiving azithromycin or amiodarone is warranted to prevent the consequences of QTc prolongation.
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA1978.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
دکتر سیدرضا سیدی، فوق تخصص قلب و عروق فلوشیپ آنژیوگرافی و آنژیوپلاستی رتبه اول بورد فوق تخصصی از دانشگاه تهران انجام تست ورزش، اکوکاردیوگرافی، هولترریتم و فشارخون